In a mission marking the end of an era, NASA astronaut and former virus hunter Kate Rubins, using NASA’s last currently contracted seat on a Russian Soyuz spacecraft, blasts off Wednesday with two cosmonaut crewmates on a flight to the International Space Station.

The first pair of RD-181 rocket engines set to launch on Orbital ATK’s redesigned Antares rocket are in the final stages of acceptance testing in Russia ahead of their export to the United States in early July, officials said.

An eight-ton cargo ship destined for the International Space Station was hoisted aboard its United Launch Alliance Atlas-Centaur booster rocket today in preparation for liftoff to the orbiting laboratory next week.