A commercial Cygnus cargo freighter packed with 3.8 tons of medical and pharmaceutical experiments, technology demonstration hardware, CubeSats and crew provisions rode an Antares rocket into orbit from Virginia’s Eastern Shore on Wednesday afternoon on the first leg of a day-and-a-half journey to the International Space Station.

Two astronauts floated outside the International Space Station Thursday and installed two new cameras on the front of the lab complex that will provide views of commercial crew ships during final approach and docking. The spacewalkers also replaced a faulty high-definition camera and closed a door that was jammed open on an external instrument.

A Russian space freighter that failed to deliver supplies to the International Space Station last week is due to re-enter Earth’s atmosphere as soon as Thursday.