A Soyuz rocket with a three-person crew heading for the International Space Station lifted off at 1357 GMT (9:57 a.m. EDT) Wednesday in the final launch currently scheduled from Gagarin’s Start, a historic site at the Baikonur Cosmodrome in Kazakhstan from where Yuri Gagarin departed on the first human spaceflight in 1961. Beginning next year, Soyuz crews will blast off from a different pad at Baikonur.

Astronauts have captured views of Hurricane Florence raging in the Atlantic Ocean and heading toward a likely landfall in the Carolinas on the U.S. East Coast, with one flight engineer calling the storm a “no-kidding nightmare.”

Two Russian cosmonauts used the International Space Station’s Poisk docking compartment as an airlock for the first time Wednesday in a six-hour 48-minute spacewalk to begin preparing the nearly identical Pirs module for removal next year. A new laboratory module will be parked in its place later.