The Antares rocket, Orbital ATK’s medium-class booster now with modern RD-181 engines, launches at 7:45 p.m. EDT (2345 GMT) from NASA’s Wallops Flight Facility on the eastern shore of Virginia.

Outgoing space station commander Shane Kimbrough and two Russian crewmates returned to Earth on Monday, riding a Soyuz capsule in a bubble of hot plasma to a parachute-assisted landing in Kazakhstan. The trio undocked from the space station at 0757 GMT (3:57 a.m. EDT) and landed on the Kazakh steppe at 1120 GMT (7:20 a.m. EDT) Monday.

A Cargo Dragon spacecraft launched to begin its fifth journey to the International Space Station, carrying with it more than 6,000 pounds of science and supplies. Liftoff happened at 9:29 p.m. EST Monday (0229 UTC Tuesday).