A Cargo Dragon spacecraft launched to begin its fifth journey to the International Space Station, carrying with it more than 6,000 pounds of science and supplies. Liftoff happened at 9:29 p.m. EST Monday (0229 UTC Tuesday).

After completing a dress rehearsal for launch day over the weekend, the four astronauts gearing up for liftoff Thursday on a SpaceX Falcon 9 rocket are in good spirits and spending time with their families in Florida before leaving the planet for a six-month expedition on the International Space Station. Forecasters with the U.S. Space Force’s 45th Weather Squadron predict an 80% chance of acceptable weather for launch early Thursday.

Four astronauts strapped into their SpaceX Crew Dragon capsule, undocked from the International Space Station and plunged to a fiery pre-dawn splashdown in the Gulf of Mexico Sunday, closing out the first operational flight of SpaceX’s futuristic touch-screen ferry ship.