SpaceX’s first upgraded Cargo Dragon spaceship departed the International Space Station Tuesday morning with more than 4,400 pounds of research specimens and other equipment, heading for splashdown Wednesday night in the Gulf of Mexico off the west coast of Florida.

NASA’s lead spacewalk flight director Royce Renfrew talks with public affairs office Rob Navias about the curtailed spacewalk by astronauts Tim Kopra and Tim Peake on January 15, 2016. Although the spacewalk’s major objective to replace a failed voltage regulator was a success, the spacewalk was cut short when a small water bubble had formed inside Kopra’s helmet.

A Japanese H-2A rocket lifted off from the Tanegashima Space Center at 0017:46 GMT Thursday (8:17:46 p.m. EDT Wednesday) with the Michibiki 2 navigation satellite designed to improve positioning and timing services over Japan.