SpaceX’s first human-rated Crew Dragon spacecraft took off Saturday from historic launch pad 39A at the Kennedy Space Center in Florida, launching NASA astronauts Doug Hurley and Bob Behnken on the first piloted orbital space mission from a U.S. spaceport in nearly a decade.

Arianespace’s first launch of 2020 lifted off at 4:05 p.m. EST (2105 GMT; 6:05 p.m. French Guiana time) Thursday from the Guiana Space Center on the northeastern shore of South America. An Ariane 5 rocket launched the Eutelsat Konnect and GSAT 30 communications satellite for Eutelsat and the Indian Space Research Organization.

SpaceX rolled out a reused Falcon 9 booster for a hold-down engine firing Wednesday at pad 40 at Cape Canaveral Air Force Station, making the first use of the launch complex since a rocket exploded there in September 2016. The static fire test accomplished Wednesday was a key step in preparations for launch of a space station cargo ship Dec. 12.