Live coverage: 400th Proton rocket takes off with Russian satellite

In a mission marking the end of an era, NASA astronaut and former virus hunter Kate Rubins, using NASA’s last currently contracted seat on a Russian Soyuz spacecraft, rocketed into orbit Wednesday with two cosmonaut crewmates on a record-setting flight to the International Space Station.

SpaceX conducted a final Launch Readiness Review on Monday ahead of the scheduled liftoff Wednesday of NASA astronauts Doug Hurley and Bob Behnken on a test flight of the Crew Dragon spacecraft to the International Space Station. Launch remains set for 4:33:33 p.m. EDT (2033:33 GMT) Wednesday, weather permitting.

An Indian radar observation satellite designed to collect information on natural disasters, pollution and monitor the military activity of India’s neighbors lifted off at 4:55 a.m. EST (0955 GMT) Wednesday on top of a Polar Satellite Launch Vehicle, the second PSLV mission in two weeks.