Live coverage: Soyuz crew lands in Kazakhstan

In a mission marking the end of an era, NASA astronaut and former virus hunter Kate Rubins, using NASA’s last currently contracted seat on a Russian Soyuz spacecraft, blasts off Wednesday with two cosmonaut crewmates on a flight to the International Space Station.

The mission is likely to be the fourth and final Starship flight before the end of 2024. Liftoff from Pad 1 at Starbase at Boca Chica Beach, Texas, is set for 4 p.m. CST (5 p.m. EST, 2200 UTC).

A United Launch Alliance Delta 4 rocket lifted off Wednesday at 2:36 p.m. EDT (1836 GMT) from Cape Canaveral on a mission to place into orbit a fresh satellite for the Global Positioning System.